3Dresyn Pharma HydroGel SLA1, Photocurable Hydrogel Resin for Pharmaceutical SLA, DLP & LCD printing

3Dresyn Pharma HydroGel SLA1, is a Photocurable hydrogel resin for pharmaceutical SLA/DLP & LCD printing (research use)

Application:

• vat photopolymerization (SLA/DLP & LCD) of pre-hydrated, drug-loadable hydrogels for R&D

Chemistry:

• proprietary hydrogel system with two alternative photoinitiation routes (water-compatible or high-speed)

• (formulation details intentionally withheld)

Wavelength:

• optimized for 365, 385, 405 nm, and visible light

Key Features & Benefits:

• pre-hydrated printing to tune swelling and release

• two kinetic routes (no disclosure): water-compatible (safe for aqueous systems) and high-speed (fast cure, near-colorless)

• low-temperature process suitable for thermolabile actives (research context).

• dimensional fidelity with smooth surfaces at 25–200 µm layers

• tunable release via hydration level, humectant, and post-print equilibration

• streamlined adoption with a practical printing window and troubleshooting guide

Recommended Uses (R&D):

• hydrogel printlets/inserts for in-vitro drug-release studies

• biomedical test components for swelling, permeability, and mechanical screening

• education and method development in pharmaceutical 3D printing

• important: research use only; end-use biomedical applications require customer biocompatibility, E/L, sterilization validation, toxicology, and regulatory clearance

Product Variants:

• base — water-compatible route (anhydrous)

• hydrated 10 / 20 / 30 — pre-hydrated options with increasing water content

• speed — high-speed route (anhydrous, near-colorless)

• (variants differ by hydration level, rheology, and photo-package; exact composition is not disclosed)

Processing Guidelines — Handling & Mixing:

• work under amber/low-blue light; use clean, dry glassware

• gentle magnetic stirring; avoid bubble entrapment and strong UV exposure

• allow temperature equilibration before printing for hydrated variants

• degas gently (rest or brief low vacuum)

Processing Guidelines — Printing (Starting Window):

• layer height: 50–100 µm (25 µm for fine features)

• environment: clean vat and platform; verify leveling and FEP integrity

Processing Guidelines — Post-Processing:

• rinse: brief wash in a matching aqueous/humectant bath; avoid aggressive solvents
• post-cure: 405 nm flood/chamber until tack-free; keep surface <40 °C for hydrated parts
• equilibration: condition in the target medium before testing release, swelling, or mechanics

Drug Incorporation Protocol (R&D Use) (composition and photoactive details intentionally omitted):

• pre-formulation checks:confirm API (Active Pharmaceutical Ingredient) identity  (≥98%) and dryness (LOD/KF); solubility screen in resin base, humectant (if applicable), and water (for hydrated variants); assess photostability/pH sensitivity; target D90 ≤ 10–20 µm (≤5–10 µm for microfeatures); avoid chemistries that may inhibit cure; if unsure, run gel-time/spot-cure test

• dosing ranges: dissolved API typically 1–10% w/w; suspended API typically 5–20% w/w

• route A — dissolved API: work under amber light; add API slowly to resin base with gentle stirring (300–600 rpm, 15–30 min); mild warming ≤40 °C if needed; de-bubble; if opalescent, switch to Route B or add ≤5% compatible co-solvent and validate

• route B — suspended API: disperse micronized API (propeller/overhead 500–1000 rpm); shear-refine if available; adjust anti-settling (target 100–1000 mPa·s at relevant shear rate); sieve 50–100 µm; de-bubble; check homogeneity (RSD ≤5%)

• printability & cure verification: confirm viscosity @25 °C; spot-cure a 10–20 µL droplet; print 5×5×2 mm coupons at 50–100 µm; stepwise increase exposure for light-absorbing APIs; verify adhesion/green strength; dimensional accuracy ±2–5% vs CAD

• washing & post-cure (API-friendly): brief rinse in matching polarity bath; avoid hot air on hydrated parts; 405 nm post-cure to tack-free with surface <40 °C; pre-condition parts in target medium before dissolution testing

• content uniformity & assay: prepare n ≥ 10 units; HPLC/UV-Vis after quantitative extraction (target AV ≤15 per USP <905>); compare pre-print top/middle/bottom draws vs finished parts

• in-vitro release (minimum viable method): appropriate buffer (pH 1.2/4.5/6.8) or sink conditions; orbital shaker 100–150 rpm or USP II; timepoints e.g., 0.5, 1, 2, 4, 8, 24 h with volume replacement; assay at API λmax; report % released vs label claim and T50

• sedimentation control: gently pre-stir vat; pause & stir on long prints (if supported) or split batches; consider thixotropic adjustment

• sterility & bioburden (as needed): maintain clean bench practice; for sterile prototypes evaluate aseptic processing or ETO and validate impact on API potency/release

• storage & stability: filled resin with API in amber bottle at 5–25 °C, dry, tightly closed; re-check viscosity & cure after 2–4 weeks; store prints light-shielded (sealed pouches for hydrated parts); periodic assay and visual inspection

Material Properties (Indicative Trends):

• swelling/permeability increase with hydration and decrease with crosslink density

• hydrated variants are softer/more elastic; anhydrous variants are stiffer (within hydrogel range

• water-compatible route may show light yellow tint; high-speed route is near-colorless

• hydration state influences thermal dimensional change

• exact values depend on printer, exposure, geometry, and hydration level

Sterilization & Stability (Customer to Validate):

• recommended ETO or aseptic processing

• assess dimensional change, mass loss, and release kinetics after sterilization

• shelf-life (unopened) 6 months at 5–25 °C, dark and dry; re-evaluate viscosity and cure before use

Safety:

• for professional users in controlled labs; wear gloves, goggles, lab coat

• avoid skin/eye contact and direct blue/UV light exposure

• fully cure residues before disposal; treat uncured waste as chemical waste per local regulations