Bioprinting of Scaffolds
Our photopolymer 3Dresyns for printing scaffolds or matrices are available in a wide range of materials with different porosities, permeabilities and mechanical properties, designed for different tissues specifications.
Scaffolds are typically divided into two main applications: functional implants for clinical and regenerative medical applications and in vitro 3D scaffolds for laboratory applications.
The aim for implantable scaffolds is to provide support to a wound site and aid eventual replacement of the scaffold by natural tissue. The requirements for functional clinical implant scaffolds are different from in vitro 3D scaffolds for laboratory applications. Functional implants must match the defect site, support and promote desired cell growth, and biodegrade without harmful effects (byproducts).
In vitro 3D scaffolds do not need specific geometric match and biodegradability since byproducts may change the chemistry and pH of the culture system. Furthermore, as the scaffold degrades and cells re-organize the matrix, the cells may not retain their 3D configuration. In vitro scaffolds should provide a more stable structure and function similar to the natural in vivo environment.
SLA DLP 3D printed scaffolds for in vitro laboratory applications are available in a variety of materials: bio-based (natural) and synthetic resin or polymeric systems, including metal and ceramic composites, as well as pure metals and ceramics.
Our Bioprinting 3Dresyns are biocompatible, provide excellent surface wetting & adsorption and are available in a wide range of porosities and mechanical properties for specific scaffold requirements.
High transparency “clear” bioprinting 3Dresyns are also available for improved imaging and easy extraction of cells from highly intricate and tortuous sized scaffolds.
Due to the variety of material and structural choices for 3D printed scaffolds, they are widely used in many applications.
Scaffolds provide a surface on which cells can grow without alterating cell culture. Their controled porosity facilitates mass transport of nutrients, oxygen, and wastes, allowing for larger culture growth.
Types of macro, micro and nano scale 3D scaffolds
- Macro-scale: Overall size and shape, dependent on specific applications
- Micro-scale: Increased porosity, pore interconnectivity, pore geometry and pore size distribution of surface topography. Micro-scale systems can be customized for different tissue types to facilitate mass transport, nutrients diffusion, metabolic wastes and can activate certain genes and modulate cellular behavior in differentiation and proliferation. Micro-scale scaffolds can have different robustness for specific applications, such as bioreactors, multiwell plate or human body
- Nano-scale: Nutrient supply and functional effects due to the size of many cell signaling molecules
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Please contact us to consult about our 3Dresyns for scaffolds and your specific requirements at: info@3Dresyns.com